Technical Data

366883
CAS Number
881639-98-1
Grade
Highly Purified
Molecular Formula
C21H18BrNO3
Molecular Weight
412.3
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
G-1 (GPR30 Agonist, AC1MJFYZ, MLS001242405)
1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone
Synonyms
GPR30 Agonist, AC1MJFYZ, MLS001242405
Chemical Name
1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]e thanone
Molecular Formula
C21 H18 BrNO 3
Molecular Weight
412.3
CAS Number
881639-98-1
Purity
≥98%
Applications
FA
Appearance: Crystalline solid
Description
G-1 is a selective and potent agonist against the GPR30 receptor, an estradiol binding receptor that contributes to both uterine and neurological responses. G-1 inhibits the production of lipopolysaccharide (LPS) induced cytokines such as IL-6 and TNF-alpha. It is also reported to block MCF-1 cell cycle progression at the G1 phase and display therapeutic effects in multiple sclerosis models.
Storage
Soluble in organic solvents such as ethanol and DMSO.
Purity
Highly Purified (~98%)
Concentration
Not determined
Form
Supplied as a crystalline solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Bologa, C. G., Revankar, C. M., Young, S. M., Edwards, B. S., Arterburn, J. B., Kiselyov, A. S., & Prossnitz, E. R. (2006). Virtual and biomolecular screening converge on a selective agonist for GPR30. Nature chemical biology, 2(4), 207-212. 2. Blasko, E., Haskell, C. A., Leung, S., Gualtieri, G., Halks-Miller, M., Mahmoudi, M., & Horuk, R. (2009). Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. Journal of neuroimmunology, 214(1), 67-77. 3. Kumar, R., Balhuizen, A., Amisten, S., Lundquist, I., & Salehi, A. (2011). Insulinotropic and antidiabetic effects of 17beta-estradiol and the GPR30 agonist G-1 on human pancreatic islets. Endocrinology, 152(7), 2568-2579.
USBio References
No references available
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