G-1 CAS 881639-98-1

CAS Number

881639-98-1

Grade

Highly Purified

Molecular Formula

C21H18BrNO3

Molecular Weight

412.3

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone

Synonyms

GPR30 Agonist, AC1MJFYZ, MLS001242405

Chemical Name

1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]e thanone

Molecular Formula

C21 H18 BrNO 3

Molecular Weight

412.3

CAS Number

881639-98-1

Purity

≥98%

Applications

Appearance: Crystalline solid

Description

G-1 is a selective and potent agonist against the GPR30 receptor, an estradiol binding receptor that contributes to both uterine and neurological responses. G-1 inhibits the production of lipopolysaccharide (LPS) induced cytokines such as IL-6 and TNF-alpha. It is also reported to block MCF-1 cell cycle progression at the G1 phase and display therapeutic effects in multiple sclerosis models.

Storage

Soluble in organic solvents such as ethanol and DMSO.

Purity

Highly Purified (~98%)

Concentration

Not determined

Form

Supplied as a crystalline solid.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Bologa, C. G., Revankar, C. M., Young, S. M., Edwards, B. S., Arterburn, J. B., Kiselyov, A. S., & Prossnitz, E. R. (2006). Virtual and biomolecular screening converge on a selective agonist for GPR30. Nature chemical biology, 2(4), 207-212. 2. Blasko, E., Haskell, C. A., Leung, S., Gualtieri, G., Halks-Miller, M., Mahmoudi, M., & Horuk, R. (2009). Beneficial role of the GPR30 agonist G-1 in an animal model of multiple sclerosis. Journal of neuroimmunology, 214(1), 67-77. 3. Kumar, R., Balhuizen, A., Amisten, S., Lundquist, I., & Salehi, A. (2011). Insulinotropic and antidiabetic effects of 17beta-estradiol and the GPR30 agonist G-1 on human pancreatic islets. Endocrinology, 152(7), 2568-2579.

USBio References

No references available

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366883 G-1 (GPR30 Agonist, AC1MJFYZ, MLS001242405) CAS: 881639-98-1

CAS Number

Grade

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

1-[4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinolin-8-yl]ethanone

References

USBio References

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