Technical Data

366885
CAS Number
133053-19-7
Grade
Highly Purified
MDL Number
MFCD04040031
Molecular Formula
C26H26N4O3
Molecular Weight
442.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
Go 6983
Gö6983, Gö 6983, 2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide
Synonyms
Gö6983, Gö 6983, 2-(1-(3-dimethylaminopropyl)-5-methoxyindol-3-yl)-3-(1H-indol-3-yl)maleimide
Chemical Name
3-[1-[3-(dimethylamino)propyl]-5-methoxyindol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione
Molecular Formula
C26 H26 N4O3
Molecular Weight
442.5
CAS Number
133053-19-7
Purity
≥98%
Applications
FA
Appearance
Crystalline solid
Description
Go 6983 is a broad fast-acting inhibitor of various isoforms of protein kinase C. It can be used to inhibit differentiation and maintain the pluripotency of embryonic stem cells and enhance stem cell viability and growth. Go 6983 is also reported to exert cardio protective effects in myocardial ischemia and inhibited intracellular Ca accumulation.
Storage
Soluble in organic solvents such as DMF and DMSO.
Purity
Highly Purified (~98%)
Concentration
Not determined
Form
Supplied as a crystalline solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Peterman, E. E., Taormina, P. II, Harvey, M., and Young, LH 2004. Go 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion. J. Cardiovasc. Pharmacol, 43, 645-656.|2. Young, L. H., Balin, B. J., Weis, M. T. (2005). Gouml; 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovascular drug reviews, 23(3), 255-272. 3. Gschwendt, M., Dieterich, S., Rennecke, J., Kittstein, W., Mueller, H. J., Johannes, F. J. (1996). Inhibition of protein kinase C mu; by various inhibitors. Inhibition from protein kinase c isoenzymes. FEBS letters, 392(2), 77-80.
USBio References
No references available
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