Technical Data

366889
CAS Number
1160927-48-9
Grade
Highly Purified
MDL Number
MFCD17480459
Molecular Formula
C15H18N2O5
Molecular Weight
306.3
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
IDE1 (1DE 1, Inducer of Definitive Endoderm 1)
1-[2-[(2-carboxyphenyl)methylene]hydrazide]-heptanedioic acid
Synonyms
1DE 1, Inducer of Definitive Endoderm 1
Chemical Name
1-[2-[(2-carboxyphenyl)methylene]hydrazide]-heptanedioic acid
Molecular Formula
C15 H18 N2O5
Molecular Weight
306.3
CAS Number
1160927-48-9
Purity
≥98%
Applications
FA
Appearance: Crystalline solid
Description
IDE1 activates the TGF-beta signaling pathway and induces definitive endoderm formation in human and mouse embryonic stem cells. It is also reported to increase the levels of Nodal expression, induce Smad2 phosphorylation and SOX17 expression.
Storage
Soluble in organic solvents such as ethanol and DMSO. DMSO up to 80mM.
Purity
Highly Purified (~98%)
Concentration
Not determined
Form
Supplied as a crystalline solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Hoveizi, E., Nabiuni, M., Parivar, K., Ai, J., & Massumi, M. (2014). Definitive endoderm differentiation of human‐induced pluripotent stem cells using signaling molecules and IDE1 in three‐dimensional polymer scaffold. Journal of Biomedical Materials Research Part A, 102(11), 4027-4036. 2. Borowiak, M., Maehr, R., Chen, S., Chen, A. E., Tang, W., Fox, J. L., & Melton, D. A. (2009). Small molecules efficiently direct endodermal differentiation of mouse and human embryonic stem cells. Cell stem cell, 4(4), 348-358. 3. Aguayo-Mazzucato, C., & Bonner-Weir, S. (2010). Stem cell therapy for type 1 diabetes mellitus. Nature Reviews Endocrinology, 6(3), 139-148.
USBio References
No references available
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