LDN193189 CAS 1062368-24-4

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366895 LDN193189 (DM-3189) CAS: 1062368-24-4

Specifications

References

CAS Number

1062368-24-4

Grade

Highly Purified

MDL Number

MFCD17169988

Molecular Formula

C25H22N6

Molecular Weight

406.5

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinolone

Synonyms

DM-3189

Chemical Name

4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinolone

Molecular Formula

C25 H22 N6

Molecular Weight

406.5

CAS Number

1062368-24-4

Purity

≥95%

Applications

Appearance: Crystalline solid

Description

LDN193189 is a dorsomorphin derivative and potent BMP pathway inhibitor. It is reported to inhibit bone morphogenetic protein (BMP) type I receptors ALK1, ALK2, ALK3, and ALK6. LDN193189 is useful for the promotion of specific cell differentiation and the study of ectopic ossification.

Storage

Soluble in ethanol and DMSO.

References

1. Boergermann, J. H., Kopf, J., Yu, P. B., Knaus, P. (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. The international journal of biochemistry cell biology, 42(11), 1802-1807. 2. Kreitzer, F. R., Salomonis, N., Sheehan, A., Huang, M., Park, J. S., Spindler, M. J., Conklin, B. R. (2013). A robust method to derive functional|neural crest cells from human pluripotent stem cells. American journal of stem cells, 2(2), 119. 3. Derwall, M., Malhotra, R., Lai, C. S., Beppu, Y., Aikawa, E., Seehra, J. S., Paul, B. Y. (2012). Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology, 32(3), 613-622.