Technical Data

366895
CAS Number
1062368-24-4
Grade
Highly Purified
MDL Number
MFCD17169988
Molecular Formula
C25H22N6
Molecular Weight
406.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
LDN193189 (DM-3189)
4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinolone
Synonyms
DM-3189
Chemical Name
4-(6-(4-(piperazin-1-yl)phenyl)pyrazolo[1,5-a]pyrimidin-3-yl)quinolone
Molecular Formula
C25 H22 N6
Molecular Weight
406.5
CAS Number
1062368-24-4
Purity
≥95%
Applications
FA
Appearance: Crystalline solid
Description
LDN193189 is a dorsomorphin derivative and potent BMP pathway inhibitor. It is reported to inhibit bone morphogenetic protein (BMP) type I receptors ALK1, ALK2, ALK3, and ALK6. LDN193189 is useful for the promotion of specific cell differentiation and the study of ectopic ossification.
Storage
Soluble in ethanol and DMSO.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Boergermann, J. H., Kopf, J., Yu, P. B., Knaus, P. (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells. The international journal of biochemistry cell biology, 42(11), 1802-1807. 2. Kreitzer, F. R., Salomonis, N., Sheehan, A., Huang, M., Park, J. S., Spindler, M. J., Conklin, B. R. (2013). A robust method to derive functional|neural crest cells from human pluripotent stem cells. American journal of stem cells, 2(2), 119. 3. Derwall, M., Malhotra, R., Lai, C. S., Beppu, Y., Aikawa, E., Seehra, J. S., Paul, B. Y. (2012). Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arteriosclerosis, thrombosis, and vascular biology, 32(3), 613-622.
USBio References
No references available
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