Technical Data

366905
CAS Number
219580-11-7
Grade
Highly Purified
MDL Number
MFCD08705327
Molecular Formula
C28H41N7O3
Molecular Weight
523.7
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
PD 173074 (PD173074, UNII-A4TLL8634Y, FGF/VEGF Receptor Tyrosine Kinase Inhibitor)
1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]urea
Synonyms
PD173074, UNII-A4TLL8634Y, FGF/VEGF Receptor Tyrosine Kinase Inhibitor
Chemical Name
1-tert-butyl-3-[2-[4-(diethylamino)butylamino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrim idin-7-yl]urea
Molecular Formula
C28 H41 N7O3
Molecular Weight
523.7
CAS Number
219580-11-7
Purity
≥98%
Applications
FA
Appearance
Crystalline solid
Description
PD 173074 is a potent and selective inhibitor of fibroblast growth factors, FGFR1 and FGFR3. It is reported to suppress the differentiation of mouse embryonic cells and promote the survival of human embryonic cells. PD 173074 potently and selectively antagonizes the neurotrophic and neurotropic actions of FGF-2 and displays anti-cancer properties.
Storage
Soluble in DMSO up to 20 mM.
Purity
Highly Purified (~98%)
Concentration
Not determined
Form
Supplied as a crystalline solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Skaper, S. D., Kee, W. J., Facci, L., Macdonald, G., Doherty, P., & Walsh, F. S. (2000). The FGFR1 Inhibitor PD 173074 Selectively and Potently Antagonizes FGF‐2 Neurotrophic and Neurotropic Effects. Journal of neurochemistry, 75(4), 1520-1527. 2. Mohammadi, M., Froum, S., Hamby, J. M., Schroeder, M. C., Panek, R. L., Lu, G. H., ... Hubbard, S. R. (1998). Crystal structure of an angiogenesis inhibitor bound to the FGF receptor tyrosine kinase domain. The EMBO journal, 17(20), 5896-5904. 3. Dimitroff, C. J., Klohs, W., Sharma, A., Pera, P., Driscoll, D., Veith, J., Bernacki, R. J. (1999). Anti-angiogenic activity of selected receptor tyrosine kinase inhibitors, PD166285 and PD173074: implications for combination treatment with photodynamic therapy. Investigational new drugs,17(2), 121-135.
USBio References
No references available
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