Pluripotin CAS 839707-37-8

CAS Number

839707-37-8

Grade

Highly Purified

MDL Number

MFCD20527253

Molecular Formula

C27H25F3N8O2

Molecular Weight

550.5

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide

Synonyms

SC-1, SC1

Chemical Name

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyr imidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide

Molecular Formula

C27H25F3N8O2

Molecular Weight

550.5

CAS Number

839707-37-8

Purity

≥98%

Applications

Appearance

Crystalline solid

Description

Pluripotin is an inhibitor of both RasGAP and ERK1. The inhibition of RasGAP is used to promote self-renewal and the inhibition of ERK1 blocks cell differentiation. Pluripotin can be conbined with leukemia inhibitory factor (LIF) to promote the derivation of embryonic cell lines from refractory strains.

Storage

Soluble in organic solvents such as DMF and DMSO. DMSO up to 45mM.

Purity

Highly Purified (~98%)

Concentration

Not determined

Form

Supplied as a crystalline solid.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1.Yang, W., Wei, W., Shi, C., Zhu, J., Ying, W., Shen, Y., ... Deng, H. (2009). Pluripotin combined with leukemia inhibitory factor greatly promotes the derivation of embryonic stem cell lines from refractory strains. Stem Cells, 27(2), 383-389. 2. Pieters, T., Haenebalcke, L., Hochepied, T., D’ Hont, J., Haigh, J. J., Van Roy, F., van Hengel, J. (2012). Efficient and user-friendly pluripotin-based derivation of mouse embryonic stem cells. Stem Cell Reviews and Reports, 8(3), 768-778. 3. Duan, H., Wang, Y., Yang, L., Qu, M., Wang, Q., Shi, W., Zhou, Q. (2012). Pluripotin enhances the expansion of rabbit limbal epithelial stem/progenitor cells in vitro. Experimental eye research,100, 52-58.

USBio References

No references available

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366906 Pluripotin (SC-1, SC1) CAS: 839707-37-8

CAS Number

Grade

MDL Number

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

N-(3-(7-(1,3-dimethyl-1H-pyrazol-5-ylamino)-1-methyl-2-oxo-1,2-dihydropyrimido[4,5-d]pyrimidin-3(4H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide

References

USBio References

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