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366907 PluriSln 1 (NSC 14613, 4-Pyridinecarboxylicacid, 2-phenylhydrazide) CAS: 91396-88-2

Specifications
References
CAS Number
91396-88-2
Grade
Highly Purified
MDL Number
MFCD02344904
Molecular Formula
C12H11N3O
Molecular Weight
213.2
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
N'-phenylpyridine-4-carbohydrazide

Synonyms
NSC 14613, 4-Pyridinecarboxylicacid, 2-phenylhydrazide
Chemical Name
N'-phenylpyridine-4-carbohydrazide
Molecular Formula
C12 H11 N3
Molecular Weight
213.2
CAS Number
91396-88-2
Purity
≥95%
Applications
FA
Appearance
Crystalline solid
Description
PluriSln 1 a stearoyl-CoA desaturase 1 (SCD1) inhibitor used to selectively eliminate undifferentiated human pluripotent stem cells. It induces apoptosis in hPSCs to the exclusion of differentiated or progenitor cells. It is reported to prevent teratoma formation in immunocompromised mice.
Storage
Soluble in organic solvents such as ethanol and DMSO. DMSO up to 100mM.
References
1. Ben-David, U., Gan, Q. F., Golan-Lev, T., Arora, P., Yanuka, O., Oren, Y. S., ... Benvenisty, N. (2013). Selective elimination of human pluripotent stem cells by an oleate synthesis inhibitor discovered in a high-throughput screen. Cell Stem Cell, 12(2), 167-179. 2. Phillips, M. I. (2014). Tumor-free iPS stem cells for heart cells. Cell Cycle, 13(10), 1519-1519. 3. Lou, K. J. (2013). Small molecules vs. teratomas. SciBX: Science-Business eXchange, 6(7).
USBio References
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