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366913 StemRegenin 1 (SR1) CAS: 1227633-49-9

Specifications
References
CAS Number
1227633-49-9
Grade
Highly Purified
MDL Number
MFCD16987861
Molecular Formula
C24H23N5OS
Molecular Weight
429.5
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
4-[2-[[2-(1-benzothiophen-3-yl)-9-propan-2-ylpurin-6-yl]amino]ethyl]phenol

Synonyms
StemRegenin-1
Chemical Name
4-[2-[[2-(1-benzothiophen-3-yl)-9-propan-2-ylpurin-6-yl]amino]ethyl]phenol
Molecular Formula
C24H23N5OS
Molecular Weight
429.5
CAS Number
1227633-49-9
Purity
≥98%
Applications
FA
Appearance
Crystalline solid
Description
StemRegenin 1 (SR1) is a selective reversible antagonist of the aryl hydrocarbon receptor with a value of 50% inhibition concentration IC50 of 127 nM in CD34+ cells. It is reported to promote the self-renewal of human hematopoietic stem cells in culture by sustaining the cellular expression of CD34. StemRegenin 1 also stimulates the proliferation and differentiation of CD34+ hematopoietic progenitor cells into dendritic cells.
Solubility
Soluble in organic solvents such as DMSO. DMSO up to 25mM.
Storage
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Purity
Highly Purified (~98%)
Concentration
Not determined
Form
Supplied as a crystalline solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Thordardottir, S., Hangalapura, B. N., Hutten, T., Cossu, M., Spanholtz, J., Schaap, N., ... Dolstra, H. (2013). The aryl hydrocarbon receptor antagonist StemRegenin 1 promotes human plasmacytoid and myeloid dendritic cell development from CD34+ hematopoietic progenitor cells. Stem cells and development, 23(9), 955-967. 2. Boitano, A. E., Wang, J., Romeo, R., Bouchez, L. C., Parker, A. E., Sutton, S. E., ... Schultz, P. G. (2010). Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells. Science, 329(5997), 1345-1348. 3. Gori, J. L., Chandrasekaran, D., Kowalski, J. P., Adair, J. E., Beard, B. C., D'Souza, S. L., Kiem, H. P. (2012). Efficient generation, purification, and expansion of CD34+ hematopoietic progenitor cells from nonhuman primateinduced pluripotent stem cells. Blood, 120(13), e35-e44.
USBio References
No references available
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