Technical Data

366914
CAS Number
293754-55-9
Grade
Highly Purified
MDL Number
MFCD03412028
Molecular Formula
C17H12F9NO3S
Molecular Weight
481.3
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
T 0901317 (T-0901317, T0901317)
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide
Synonyms
T-0901317, T0901317
Chemical Name
N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzen esulfonamide
Molecular Formula
C17H12F9NO3
Molecular Weight
481.3
CAS Number
293754-55-9
Purity
≥98%
Applications
FA
Appearance
Crystalline solid
Description
T0901317 is a potent agonist for the high affinity liver X receptor, which up-regulates ABC1 gene expression. It is reported that it can be used to lower cholesterol levels in serum and liver, to suppress the proliferation of breast and prostate cancer cells, and to decrease amyloid beta production.
Solubility
Soluble in organic solvents such as ethanol and DMSO. DMSO up to 90mM.
Storage
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Purity
Highly Purified (~98%)
Concentration
Not determined
Form
Supplied as a crystalline solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Koldamova, R. P., Lefterov, I. M., Staufenbiel, M., Wolfe, D., Huang, S., Glorioso, J. C., ... Lazo, J. S. (2005). The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease. Journal of Biological Chemistry, 280(6), 4079-4088. 2. Mitro, N., Vargas, L., Romeo, R., Koder, A., Saez, E. (2007). T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR. FEBS letters, 581(9), 1721-1726. 3. Chisholm, J. W., Hong, J., Mills, S. A., Lawn, R. M. (2003). The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. Journal of lipid research, 44(11), 2039-2048.
USBio References
No references available
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