T 0901317 CAS 293754-55-9

CAS Number

293754-55-9

Grade

Highly Purified

MDL Number

MFCD03412028

Molecular Formula

C17H12F9NO3S

Molecular Weight

481.3

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide

Synonyms

T-0901317, T0901317

Chemical Name

N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzen esulfonamide

Molecular Formula

C17H12F9NO3

Molecular Weight

481.3

CAS Number

293754-55-9

Purity

≥98%

Applications

Appearance

Crystalline solid

Description

T0901317 is a potent agonist for the high affinity liver X receptor, which up-regulates ABC1 gene expression. It is reported that it can be used to lower cholesterol levels in serum and liver, to suppress the proliferation of breast and prostate cancer cells, and to decrease amyloid beta production.

Solubility

Soluble in organic solvents such as ethanol and DMSO. DMSO up to 90mM.

Storage

Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Purity

Highly Purified (~98%)

Concentration

Not determined

Form

Supplied as a crystalline solid.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Koldamova, R. P., Lefterov, I. M., Staufenbiel, M., Wolfe, D., Huang, S., Glorioso, J. C., ... Lazo, J. S. (2005). The liver X receptor ligand T0901317 decreases amyloid β production in vitro and in a mouse model of Alzheimer's disease. Journal of Biological Chemistry, 280(6), 4079-4088. 2. Mitro, N., Vargas, L., Romeo, R., Koder, A., Saez, E. (2007). T0901317 is a potent PXR ligand: implications for the biology ascribed to LXR. FEBS letters, 581(9), 1721-1726. 3. Chisholm, J. W., Hong, J., Mills, S. A., Lawn, R. M. (2003). The LXR ligand T0901317 induces severe lipogenesis in the db/db diabetic mouse. Journal of lipid research, 44(11), 2039-2048.

USBio References

No references available

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366914 T 0901317 (T-0901317, T0901317) CAS: 293754-55-9

CAS Number

Grade

MDL Number

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide

References

USBio References

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