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411982 13,14-Dihydro-15-keto-PGD2 CAS: 59894-07-4

Specifications
References
CAS Number
59894-07-4
Grade
Highly Purified
Molecular Formula
C₂₀H₃₂O₅
Molecular Weight
352.47
EU Commodity Code
38220090
Shipping Temp
Dry Ice
Storage Temp
-80°C
9α-hydroxy-11,15-dioxo-prost-5Z-en-1-oic acid

13,14-Dihydro-15-keto-PGD2 is a metabolite of prostaglandin D2 and a selective CRTh2/DP2 receptor agonist. CRTh2/DP2 receptors play crucial roles in atopic dermatitis, asthma, and other inflammatory diseases.

Synonyms
9α-hydroxy-11,15-dioxo-prost-5Z-en-1-oic acid
CAS No
59894-07-4
Molecular Formula
C₂₀H₃₂O₅
Molecular Weight
352.47
Appearance
Liquid in methyl acetate
Purity
≥95%
Solubility
DMF: 50mg/ml DMSO: 30mg/ml Ethanol: 50mg/ml PBS pH 7.2: 2.5mg/ml
Storage and Stability
Store at -80°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Rangachari, P.K., and Betti, P.A. Biological activity of metabolites of PGD2 on canine proximal colon. Am. J. Physiol. 264(5 Pt 1), G886-G894 (1993).|2. Hirai, H., Tanaka, K., Yoshie, O., et al. Prostaglandin D2 selectivity induces chemotaxis in T helper type 2 cells, eosinophils, and basophils via seven-transmembrane receptor CRTH2. J. Exp. Med. 193(2), 255-261 (2001).|3. Liston, T.E., and Roberts, L.J., II. Metabolic fate of radiolabeled prostaglandin D2 in a normal human male volunteer. J. Biol. Chem. 260(24), 13172-13180 (1985).|4. Morrow, J.D., Prakash, C., Awad, J.A., et al. Quantification of the major urinary metabolite of prostaglandin D2 by a stable isotope dilution mass spectrometric assay. Anal. Biochem. 193(1), 142-148 (1991).|Product Citations|Gomez-Abellan, V., Montero, J., Lopez-Munoz, A., et al. Professional phagocytic granulocyte-derived PGD2 regulates the rsolution of inflammation in fish. Develop. Comp. Immunol. 52(2), 182-191 (2015).
USBio References
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