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418880 2-Methylthio-ADP Trisodium Salt CAS: 475193-31-8

Specifications
References
CAS Number
475193-31-8
Grade
Highly Purified
Molecular Formula
C₁₁H₁₄N₅Na₃O₁₀P₂S
Molecular Weight
539.24
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
2-(Methylthio)adenosine 5'-Diphosphate Trisodium Salt; 2-MeSADP; 2-Methylthio-ADP

2-Methylthio-ADP trisodium salt is a P2Y1, P2Y12 and P2Y13 agonist. It is used in biological study of activation of P2Y1 P2Y12 and P2Y13 protein promoted purinergic ATP signal transduction mediated calcium flux in podocyte isolated from rat glomerulus.

Synonyms
2-(Methylthio)adenosine 5'-Diphosphate Trisodium Salt; 2-MeSADP; 2-Methylthio-ADP
CAS Number
475193-31-8 Alternate CAS No: 34983-48-7
Molecular Formula
C₁₁H₁₄N₅Na₃O₁₀P₂S
Molecular Weight
539.24
Appearance
White to off-white solid
Solubility
~10mg/ml MAKE FRESH
Storage and Stability
Lyophilized product is stable for 6 months after receipt at -20°C. Reconstitute with sterile PBS. MAKE FRESH USE WITHIN 24 HOURS. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Important Note
Toxicity and Hazards
 
References
1. Sak, K., and Webb, T.E. A retrospective of recombinant P2Y receptor subtypes and their pharmacology. Arch. Biochem. Biophys. 397(1), 131-136 (2002). 2. Zhang, F.L., Luo, L., Gustafson, E., et al. P2Y13: Identification and characterization of a novel Gαi-coupled ADP receptor from human and mouse. J. Pharmacol. Exp. Ther. 301(2), 705-713 (2002).. 3. Macfarlane, D.E., Srovastava, P.C., and Mills, D.C. 2-Methylthioadenosine[β-32P]diphosphate. An agonist and radioligand for the receptor that inhibits the accumulation of cyclic AMP in intact blood platelets. J. Clin. Invest. 71(3), 420-428 (1983). 4. Ilatovskaya, D., et al.: Am J Physiol, 305, C1050 (2013)
USBio References
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