Ascofuranone is an isoprenoid antibiotic originally isolated as a hypolipidemic substance from the phytopathogenic fungus, Ascochyta viciae by researchers at Chugai Pharmaceutical Co., Japan in 1973. Ascofuranone demonstrates antitumor activity against FM3A murine mammary, B16 melanoma and Lewis lung carcinomas. Ascofuranone increases splenic cytotoxicity and phagocytic activity of host animal cells. Ascofuranone targets c-Myc independent of p53. Ascofuranone also inhibits respiration, mitochondrial uptake and glycerol-3-phosphate dehydrogenase. Ascofuranone is active against trypanosomes.
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