Technical Data

444429
CAS Number
54-05-7
Grade
Highly Purified
MDL Number
MFCD00024009
Molecular Formula
C₁₈H₂₆ClN₃
Molecular Weight
319.87
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
Chloroquine
N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine; (±)-Chloroquine;|7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline; Aralen; Artrichin; Bipiquin; Capquin; Chloraquine; Chlorochin; Chlorolex; loquin; E-Vivax; Hcqs; Maliago; NSC 187208; Nivaquinp; Premoquine; RP 3377; Reumachlor; Ronaquine;|Rosq; ST 121; ST 121 (Pharmaceutical); Sequin

Chloroquine is a 4-aminoquinolone that is used to prevent and treat malaria, caused by parasitic protozoan from the Plasmodium genus. Chloroquine is are an schizonticidal agent and is a widely prescribed antimalarial compound. The antiviral activity of chloroquine in vitro has been reported in 1960’s and recent publications have brought attention to its possible benefits in the treatment of COVID-19 patients, infected with the newly emerged coronavirus (SARS-CoV-2). Current evidence shows that chloroquine inhibits SARS CoV-2 entry in host cells by interfering with endocytosis and the glycoprofile on the S-glycoprotein.

Synonyms
N4-(7-Chloro-4-quinolinyl)-N1,N1-diethyl-1,4-pentanediamine; (±)-Chloroquine; 7-Chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]quinoline; Aralen; Artrichin; Bipiquin; Capquin; Chloraquine; Chlorochin; Chlorolex; loquin; E-Vivax; Hcqs; Maliago; NSC 187208; Nivaquinp; Premoquine; RP 3377; Reumachlor; Ronaquine; Rosq; ST 121; ST 121 (Pharmaceutical); Sequin
CAS No
54-05-7
Molecular Formula
C₁₈H₂₆ClN₃
Molecular Weight
319.87
Purity
≥98% (HPLC)
Appearance
White to light yellow powder
Melting Point
89-93°C
Specific Rotation
-1.0 to +1.0 deg (C=1, methanol)
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at 4°C. Stable for 6 months after receipt. Under inert atmosphere
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
 All products should be handled by qualified personnel only, trained in laboratory procedures.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Laufer, M. et al.: PLoS One., 7, e42284 (2012). 2. H2. angartner, S. et al.: Drug Test. ANal., 5:777 (2013). 3. Wang et al, 2020. Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research 30:269–271 affecting.
USBio References
No references available
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