467226
CAS Number
195875-84-4Grade
Highly PurifiedMolecular Formula
C₁₇H₂₃Cl₂NOMolecular Weight
328.28EU Commodity Code
38220090Shipping Temp
RTStorage Temp
-20°CTesofensine
(1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane; [1R-(2-endo,3-exo)]-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane; NS 2330
Tesofensine, is a serotonin–noradrenaline–dopamine reuptake inhibitor from the phenyltropane family of drugs, which is is currently in clinical development for the treatment of obesity.
Synonyms
(1R,2R,3S,5S)-3-(3,4-Dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane; [1R-(2-endo,3-exo)]-3-(3,4-dichlorophenyl)-2-(ethoxymethyl)-8-methyl-8-azabicyclo[3.2.1]octane; NS 2330
Molecular Formula
C₁₇H₂₃Cl₂NO
Appearance
Off-white to light yellow sticky solid
Solubility
Chloroform (Slightly), Methanol (Slightly)
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Axel, A., M,D., Mikkelsen, J.D., and Hansen, H.H. Tesofensine, a novel triple monoamine reuptake inhibitor, induces appetite suppression by indirect stimulation of α1 adrenoceptor and dopamine D1 receptor pathways in the diet-induced obese rat. Neuropsychopharmacology 35(7), 1464-1476 (2010).|2. van de Giessen, E., de Bruin, K., la Fleur, S.E., et al. Triple monoamine inhibitor tesofensine decreases food intake, body weight, and striatal dopamine D2/D3 receptor availability in diet-induced obese rats. Eur. Neuropsychopharmacol. 22(4), 290-299 (2012).USBio References
No references available