Technical Data

469355
CAS Number
3856-25-5
Grade
Highly Purified
Molecular Formula
C₁₅H₂₄
Molecular Weight
204.35
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
4°C
α-Copaene
Copaene; 1,3-Dimethyl-8-(1-methylethyl)-tricyclo[4.4.0.02,7]dec-3-ene; 8-Isopropyl-1,3-dimethyl-tricyclo[4.4.0.02,7]dec-3-ene; (1R,2S,6S,7S,8S)-(-)-8-Isopropyl-1,3-dimethyl-tricyclo[4.4.0.02,7]dec-3-ene; (1R,2S,6S,7S,8S)-1,3-Dimethyl-8-(1-methylethyl)tricyclo[4.4.0.02,7]dec-3-ene; (-)-Copaene; (-)-α-Copaene; (1R,2S,6S,7S,8S)-(-)-8-Isopropyl-1,3-dimethyltricyclo[4.4.0.02,7]dec-3-ene; Aglaiene

α-Copaene is a tricyclic sesquiterpenes and can be extracted from the oil of S. aethiopis. It also exhibit anti-plasmodial activity against P. falciparum in culture. α-Copaene is a sesquiterpene found in a variety of plants, including Cannabis, that has antiproliferative and antioxidant properties.1,2 It inhibits proliferation of primary rat neurons and N2a rat neuroblastoma cells in a concentration-dependent manner and cultured human lymphocytes when used at concentrations greater than 100mg/L.2,3 α-Copaene (25mg/L) increases total antioxidant capacity in primary rat neurons and N2a neuroblastoma cells, as well as cultured human lymphocytes, when used at concentrations of 50 and 100mg/L.

Synonyms
Copaene; 1,3-Dimethyl-8-(1-methylethyl)-tricyclo[4.4.0.02,7]dec-3-ene; 8-Isopropyl-1,3-dimethyl-tricyclo[4.4.0.02,7]dec-3-ene; (1R,2S,6S,7S,8S)-(-)-8-Isopropyl-1,3-dimethyl-tricyclo[4.4.0.02,7]dec-3-ene; (1R,2S,6S,7S,8S)-1,3-Dimethyl-8-(1-methylethyl)tricyclo[4.4.0.02,7]dec-3-ene; (-)-Copaene; (-)-α-Copaene; (1R,2S,6S,7S,8S)-(-)-8-Isopropyl-1,3-dimethyltricyclo[4.4.0.02,7]dec-3-ene; Aglaiene
CAS No
3856-25-5
Molecular Formula
C₁₅H₂₄
Molecular Weight
204.35
Appearance
Clear, colorless oil
Purity
As reported
Solubility
Chloroform (Slightly), Methanol (Slightly)
Storage and Stability
Store at 4°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Marchini, M., Charvoz, C., Dujourdy, L., et al. Multidimensional analysis of cannabis volatile constituents: Identification of 5,5-dimethyl-1-vinylbicyclo[2.1.1]hexane as a volatile marker of hashish, the resin of Cannabis sativa L. J. Chromatogr. A. 1370, 200-215 (2014).|2. Türkez, H., Çelik, K., and Toǧar, B. Effects of copaene, a tricyclic sesquiterpene, on human lymphocytes cells in vitro. Cytotechnology 66(4), 597-603 (2014).|3. Turkez, H., Togar, B., Tatar, A., et al. Cytotoxic and cytogenetic effects of α-copaene on rat neuron and N2a neuroblastoma cell lines. Biologia 69(7), 936-942 (2014).|4. Boyom, F. F., et al.: Phytochemistry 64, 1269 (2003)|5. Rustaiyan, A., et al.: Flavour Frag. J 14, 276 (1999)|
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