β-Nicotinamide-d4 Mononucleotide CAS 1094-61-7

CAS Number

1094-61-7

Grade

Highly Purified

Molecular Formula

C₁₁H₁₁D₄N₂O₈P

Molecular Weight

338.24

EU Commodity Code

38220090

Shipping Temp

Storage Temp

-20°C

3-(Aminocarbonyl)-1-(5-O-phosphono-β-D-ribofuranosyl)pyridinium-d4 Inner Salt

β-Nicotinamide-d4 Mononucleotide is the labelled analogue of a product of the extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) reaction and a key NAD+ intermediate. It ameliorates glucose intolerance by restoring NAD+ levels in HFD-induced T2D mice. It also enhances hepatic insulin sensitivity and restores gene expression related to oxidative stress, inflammatory response, and circadian rhythm, partly through SIRT1 activation.

Synonyms

3-(Aminocarbonyl)-1-(5-O-phosphono-β-D-ribofuranosyl)pyridinium-d4 Inner Salt

CAS No

1094-61-7 unlabeled

Molecular Formula

C₁₁H₁₁D₄N₂O₈P

Molecular Weight

338.24

Appearance

White to off-white solid

Purity

≥95%

Melting Point

>113°C (dec.)

Solubility

Methanol (Slightly), Water (Slightly)

Storage and Stability

May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

References

Yoshino, J. et al.: Cell Metab., 14, 528 (2011); Caton, P.W. et al.: Diabetologia, 54, 3083 (2011); Formentini, L. et al.: BIochem. Pharmacol., 77, 1612 (2009)