A2295-11L1
CAS Number
111278-01-4Grade
Highly PurifiedMolecular Formula
C31H44O6Molecular Weight
512.68EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
-20°CAnguinomycin A (5-Demethyl-leptomycin A, KR 2827A, Antibiotic KR 2827A)
5-Demethyl-leptomycin A, KR 2827A, Antibiotic KR 2827A
Anguinomycin A, isolated from a Streptomyces sp., displays nanomolar cytotoxicity to murine P388 leukemia cells. In addition, it shows antitumour activity in mice against murine Lewis lung carcinoma and P388 leukemia. Anguinomycin A is an analogue of Leptomycin B, an inhibitor of nuclear export of proteins.
Solubility: Soluble in ethanol or methanol. Ethanol recommended. Unstable in DMSO.
Related to: Leptomycin A, Leptomycin B, Kazusamycin A, Kazusamycin B
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Anguinomycins C and D, new antitumor antibiotics with selective cytotoxicity against transformed cells. |Hayakawa Y. et al. J. Antibiot. 1995, 48, 954. 2. New antitumor antibiotics, anguinomycins A and B. Hayakawa Y. et al. J. Antibiot. 1987, 40, 1349.USBio References
No references available