A3690
CAS Number
26166-39-2Grade
Highly PurifiedMolecular Formula
C23H29ClO4Molecular Weight
404.9EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
+4°CAscochlorin (Antibiotic LL-Z 1272 gamma)
Antibiotic LL-Z 1272 gamma
The antitumour fungal metabolite ascochlorin specifically inhibits matrix metalloproteinase-9 (MMP9) activity through suppression of activator protein-1 (AP-1) dependent induction of MMP-9 gene expression. Via AP-1 suppression ascochlorin selectively kills MX-1 cells, a human breast cancer cell line lacking estrogen receptors. Ascochlorin also shows activity against Newcastle disease and herpes simplex viruses.
Solubility: Soluble in ethanol, methanol, DMF or DMSO.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Ascochlorin inhibits matrix metalloproteinase-9 expression by suppressing activator protein-1-mediated |gene expression through the ERK1/2 signaling pathway: inhibitory effects of ascochlorin on the invasion |of renal carcinoma cells. Hong S. et al. J. Biol. Chem. 2005, 280, 25202. |2. Selective cytotoxicity of ascochlorin in ER-negative human breast cancer cell lines. Sakaguchi K. et al. |Biochem. Biophys. Res. Commun. 2005, 329, 46. |3. Ascochlorin derivatives as ligands for nuclear hormone receptors. Togashi M. et al. J. Med. Chem. 2003, |46, 4113.USBio References
No references available