Technical Data

A4447-01
CAS Number
65195-56-4
Grade
Highly Purified
Molecular Formula
C47H70O14
Molecular Weight
859.1
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
Avermectin B1b (Antibiotic C 076B1b)
Antibiotic C 076B1b

Avermectin B1b is the minor component (<20%) of the commerically available anthelmintic marketed as Abamectin(R) used to control parasitic nematodes in livestock. Avermectin B1b contains a isopropyl residue in the 24-position. In vitro and in vivo studies have shown this analogue to be active but less potent than the B1a analogue

Purity: >99% by HPLC
Solubility: Soluble in ethanol, methanol, DMF or DMSO.
Related to: Avermectin B1a, Milbemycin A4, Milbemycin A3, Milbemycin D, Nemadectin
Source
Streptomyces avermitilis
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by |reducing muscle membrane resistance. Fritz L.C. et al. Proc. Natl Acad. Sci. USA 1979, 76, 2062. |2. Solubilization and characterization of a high affinity ivermectin binding site from Caenorhabditis elegans. |Cully D.F. et al. Mol Pharmacol. 1991, 40, 326. |3. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. |Wolstenholme A.J. & Rogers A.T. Parasitology 2005, 131, S85-95.
USBio References
No references available
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