Avermectin B1b CAS 65195-56-4

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A4447-01 Avermectin B1b (Antibiotic C 076B1b) CAS: 65195-56-4

Specifications

References

CAS Number

65195-56-4

Grade

Highly Purified

Molecular Formula

C47H70O14

Molecular Weight

859.1

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

Antibiotic C 076B1b

Avermectin B1b is the minor component (<20%) of the commerically available anthelmintic marketed as Abamectin(R) used to control parasitic nematodes in livestock. Avermectin B1b contains a isopropyl residue in the 24-position. In vitro and in vivo studies have shown this analogue to be active but less potent than the B1a analogue

Purity: >99% by HPLC

Solubility: Soluble in ethanol, methanol, DMF or DMSO.

Related to: Avermectin B1a, Milbemycin A4, Milbemycin A3, Milbemycin D, Nemadectin

Source

Streptomyces avermitilis

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Avermectin B1a irreversibly blocks postsynaptic potentials at the lobster neuromuscular junction by |reducing muscle membrane resistance. Fritz L.C. et al. Proc. Natl Acad. Sci. USA 1979, 76, 2062. |2. Solubilization and characterization of a high affinity ivermectin binding site from Caenorhabditis elegans. |Cully D.F. et al. Mol Pharmacol. 1991, 40, 326. |3. Glutamate-gated chloride channels and the mode of action of the avermectin/milbemycin anthelmintics. |Wolstenholme A.J. & Rogers A.T. Parasitology 2005, 131, S85-95.