B0003-73
CAS Number
98813-13-9Grade
Highly PurifiedMolecular Formula
C₃₅H₅₆O₈Molecular Weight
604.8EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
4°CBafilomycin D (Tubaymycin, Antibiotic 3D5)
Tubaymycin, Antibiotic 3D5
Bafilomycin D shares the same mode of action as bafilomycin A1 which has been the analog of choice in cell biology studies of the role of ATPase. Bafilomycin D contains the ring opened side chain and is a much more stable analog of bafilomycin A1. In-house data demonstrate that bafilomycin D is also a much more selective inhibitor of mammalian cells than bafilomycin A which exhibits a broad profile against tumor cells, fungi and nematodes. Limited availability has restricted a more in depth investigation of this metabolite.
Source
Streptomyces sp. MST-AS5343
Molecular Formula
C₃₅H₅₆O₈
Solubility
Soluble in ethanol, methanol, DMF or DMSO.
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with ethanol, methanol, DMF or DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Streptomyces sp. MST-AS5343
Form
Supplied as a white solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. The structure of novel insecticidal macrolides: bafilomycin D and E, and oxhygrolidin. Kretschmer, A., et al., Agric. Biol. Chem. 49: 2509 (1985). 2. Bafilolides, potent Inhibitors of the motility and development of the free-living stages of parasitic nematodes. Lacey, E., et al., Int. J. Parasitol. 25: 349 (1995).USBio References
No references available