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B1085-32C Bexarotene, Free Acid (Targretin, Targretyn, Targrexin, LGD-1069, LG 1069, LG100069, SR-11247) CAS: 153559-49-0

Specifications
References
CAS Number
153559-49-0
Grade
Highly Purified
Molecular Formula
C24H28O2
Molecular Weight
348.48
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic Acid; LG 100069; LG 1069; LG 69; LGD 1069; RO 26-4455; SR 11247; Targret; Targretin; Targretyn; Targrexin

Bexarotene (LGD-1069) is a synthetic retinoid analog with specific affinity for the retinoid X receptor and belongs to a group of compounds called rexinoids. It is an oral, noncytotoxic drug that was approved in Europe and in the U.S.A. for the treatment of refractory advanced-stage cutaneous T-cell lymphomas (CTCL).

Synonyms
4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)ethenyl)benzoic Acid; LG 100069; LG 1069; LG 69; LGD 1069; RO 26-4455; SR 11247; Targret; Targretin; Targretyn; Targrexin
CAS No
153559-49-0
Molecular Formula
C24H28O2
Molecular Weight
348.48
Appearance
White to off-white solid
Purity
≥99%
Melting Point
230-231°C
Solubility
DMSO (50mg/ml, clear, colorless solution); Soluble in ethanol at 10mg/ml with warming; very poorly soluble in water. Maximum solubility in plain water is estimated to be about 10-50uM.
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
1. Gniadecki, R., et al. "The optimal use of bexarotene in cutaneous T-cell lymphoma." Br. J. Dermatol. 157:433-440 (2007). 2. Rigas, J.R. and Dragnev, K.H. "Emerging Role of Rexinoids in Non-Small Cell Lung Cancer: Focus on Bexarotene." The Oncologist 10:22-33 (2005). 3. Wu, K., et al. "The retinoid X receptor-selective retinoid, LGD1069, prevents the development of estrogen receptor-negative mammary tumors in transgenic mice." Cancer Res. 62:6376-6380 (2002). 3. Ye,n W.C. and Lamph, W.W. "A selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced prostate cancer." Prostate 66:305-316 (2006). 4. Yen, W.C. and Lamph, W.W. "The selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced breast carcinoma." Mol. Cancer Ther. 4:824-834 (2005). 5. Yen, W.C., et al. "A selective retinoid X receptor agonist bexarotene (Targretin) prevents and overcomes acquired paclitaxel (Taxol) resistance in human non-small cell lung cancer." Clin. Cancer Res. 10:8656-8664 (2004).
USBio References
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