B2105-59
CAS Number
9041-93-4Grade
Highly PurifiedMDL Number
MFCD00070310CMolecular Formula
C55H84N17O21S+. H2SO4Molecular Weight
1513.6EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
-20°CBleomycin complex (as sulfate salts)
Blenoxane; Blexane; Bleo
Bleomycin is a complex of 11 glycopeptide antitumor antibiotics originally isolated from Streptomyces verticillus in 1972. The dominant components of the complex are bleomycin A2 and B2 and typically represent >90% of the total weight with the remainder comprising the minor analogues. Bleomycins have found clinical application in the treatment of a range of tumors. Bleomycins act by intercalation of DNA and RNA. In the presence of oxygen and metal ions, notably copper and iron, bleomycins form a pseudo- enzyme that induces DNA cleavage.
Solubility: Soluble in water, methanol with moderate ethanol solubility
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Streptomyces sp. MST-AS4458
Form
Supplied as an off-white solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Takita T. et al., J. Antibiot. 1972, 25, 755. 2. Kross J. et al., Biochemistry 1982, 21, 3711. 3. Kross et al., Biochemistry 1982, 21, 4310.USBio References
No references available