N-Boc-erythro-sphingosine ((2S,3R,4E)-2-tert-Butyloxycarbonylamino-4-octadecen-1,3-diol)
(2S,3R,4E)-2-tert-Butyloxycarbonylamino-4-octadecen-1,3-diol
The N-Boc protected Sphingosine, a selective inhibitor of protein kinase C activity and phorbol dibutyrate binding in vitro in human platelets; does not inhibit protein kinase A or myosin light chain kinase; inhibits calmodulin-dependent enzymes.
Solubility
Chloroform, Dichloromethane, Ethyl Acetate, Methanol
Method for determining identity: HNMR Spectroscopic Analysis; conforms to structure.
TLC conditions
SiO2; Hexane: Ethyl Acetate; 2:1; Visualized with AMCS; Single spot; Rf=0.2.
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
