Captopril (([2S]-N-[3-Marcapto-2-methylpropionyl]-L-proline)
([2S]-N-[3-Marcapto-2-methylpropionyl]-L-proline
Orally active angiotensin-converting enzyme (ACE) inhibitor.
Form
White crystalline solid
Solubility
Chloroform, Ethanol, Methanol
TLC Conditions
SiO2; Dichloromethane: Methanol: Acetic Acid; 150: 10: 1; Visualized with AMCS; single spot; Rf=0.65
Specific Rotation
-127.3º (c=1.7, Ethanol)
Method for determining Identity
Proton NMR Spectroscopic Anslysis and Optical Rotation
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
