C2388-15X-APC
Grade
Affinity PurifiedEU Commodity Code
30021010Shipping Temp
Blue IceStorage Temp
4°C Do Not FreezeNotes
BSA Free
CD36 (gpIIIb, gpIV, Thrombospondin Receptor) (BSA & Azide Free) (APC)
CD36 (also known as platelet glycoprotein IV, OKM5-antigen, or platelet glycoprotein IIIb) acts as a receptor for thrombospondin (TSP), collagen, falciparum malaria parasitized erythrocytes, and sickle erythrocytes. It also functions as a scavenger receptor, mediating macrophage uptake of oxidized low density lipoprotein (LDL), and apoptotic polymorphonuclear leukocytes (PMN). CD36 plays a role in platelet aggregation, macrophage foam cell development, inflammation, and the tissue ischaemia observed in sickle cell disease and cerebral malaria.
Applications
Suitable for use in Function Blocking, Flow Cytometry, Immunofluorescence and Immunohistochemistry. Not suitable for use in Western Blot. Other applications have not been tested.
Recommended Dilutions
Immunohistochemistry: Frozen sections Optimal dilutions to be determined by the researcher.
Storage and Stability
Store product at 4°C in the dark. DO NOT FREEZE! Stable at 4°C for 12 months after receipt as an undiluted liquid. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. Caution: APC conjugates are sensitive to light. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Note: Applications are based on unconjugated antibody.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Kishimoto, T., et al., eds. Leukocyte Typing VI, p636-643 and p1136-1137 (1997), Garland Publishing, Inc, New York and London. 2. Greenwalt, D.E., Ikeda, H.,Tandon, N.N., Jamieson, G.A.: Membrane glycoprotein CD36: a review of its roles in adherence, signal transduction, and transfusion medicine. Blood 80: 1105 (1992). 3. Savill, J., et al.: Thrombospondin cooperates with CD36 and the vitronectin receptor in macrophage recognition of neutrophils undergoing apoptosis. J. Clin. Invest. 90(4): 1513-1522 (1992). 4. Stomski, F.C., et. al., Experimental Cell Research 198(1): 85-92 (1992). 5. Biggs, B.A., et al., Journal of Experimental Medicine 171(6): 1883-1892 (1990).USBio References
No references available