Technical Data

C2600
CAS Number
169590-42-5
Grade
Highly Purified
Molecular Formula
C17H14F3N3O2S
Molecular Weight
381.37
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
Celecoxib (Celebrex, 4-[5-(4-Methylphenyl)-3-trifluoromethyl)-1H-pyrazol-yl]benzenesulfonamide)
Celecoxib, 4-[5-(4-Methylphenyl)-3-trifluoromethyl)-1H-pyrazol-yl]benzenesulfonamide

Celecoxib is a highly selective COX-2 inhibitor and primarily inhibits prostaglandin production. Celecoxib is approximately 7.6-fold more selective for COX-2 inhibition over COX-1. This specificity allows celecoxib to reduce inflammation and pain while minimizing gastrointestinal adverse drug reactions (e.g. stomach ulcers) that are common with non-selective non-steroidal anti-inflammatory drugs (NSAIDs).

Synonyms
Celecoxib, 4-[5-(4-Methylphenyl)-3-trifluoromethyl)-1H-pyrazol-yl]benzenesulfonamide
CAS Number
169590-42-5
Molecular Formula
C17H14F3N3O2S
Molecular Weight
381.37
Appearance
White solid
Purity
≥99%
Melting Point
157-159°C
Solubility
DMSO, Dichloromethane, Ether, Ethyl Acetate, Methanol. Soluble in DMSO at 200mg/ml; soluble in ethanol at 100mg/ml; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-50uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Pfizer Compound

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Silverstein, F.E., et al. "Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study." JAMA. 284: 1247-1255 (2000). 2. Caldwell, B., et al. "Risk of cardiovascular events and celecoxib: a systematic review and meta-analysis." J. R. Soc. Med. 99: 132-140 (2006). 3. Koki, A.T. and Masferrer, J.L. "Celecoxib: a specific COX-2 inhibitor with anticancer properties." Cancer Control. 9: 28-35 (2002). 4. Gierse, J.K., et al. "Kinetic basis for selective inhibition of cyclo-oxygenases." Biochem J. 339: 607-614 (1999).
USBio References
No references available
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