Chaetocin CAS 28097-03-2

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C3430-45 Chaetocin (Chetocin) CAS: 28097-03-2

Specifications

References

CAS Number

28097-03-2

Grade

Highly Purified

Molecular Formula

C30H28N6O6S4

Molecular Weight

696.85

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

4°C/-20°C

Chetocin

Chaetocin is an epithiodioxopiperazine antibiotic that has recently shown promise as a selective antitumor agent. Chaetocin is a specific inhibitor for the lysine-specific methyltransferase SU(VAR)3-9 both in vitro and in vivo. Chaetocin is dramatically accumulated in cancer cells via a process inhibited by glutathione. Inside the cell, its activity is mediated by the imposition of oxidative stress.

DMSO, DMF, methanol and ethanol. Poorly soluble in water

Source

Chaetomium sp.

Purity

> 99% by HPLC

Form

White solid

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Isolation and configuration of Chaetocin. Hauser, D. et al. Helv. Chim. Acta 1970, 53, 1061. 2. Identification of a specific inhibitor of the histone methyltransferase SU(VAR)3-9. Greiner D. et al. Nature Chem. Biol. 2005, 1, 143. 3. Chaetocin, a promising new anti-myeloma agent with in vitro and in vivo activity mediated via imposition of oxidative stress. Isham C.R. et al. Blood 2007, 109, 2579.