Technical Data

C5071-30
CAS Number
82196-88-1
Grade
Highly Purified
Molecular Formula
C28H28O9
Molecular Weight
508.52
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
+4°C
Chrysomycin A (Chrysomycin V, Virenomycin V, Albacarcin V)
Chrysomycin V, Virenomycin V, Albacarcin V

Chrysomycin A is the major analogue in a complex of C-glycoside antitumor actives isolated from Streptomyces. Chrysomycin A, with a vinyl group in the 8-position, is the most potent analogue of the complex, which is thought to act as an inhibitor of the catalytic activity of human topoisomerase II. Chrysomyin A has a potent antibacterial, antifungal, antiviral and antitumor profile. More recent research on related metabolites, the gilvocarcins, suggests that chrysomycins may act as photoactivated, crosslinkers of DNA to histones.

Purity: >99% by HPLC
Solubility: Soluble in DMF or DMSO. Moderately soluble in methanol or ethanol.
Related to: Chrysomycin B, Gilvocarcin M, Gilvocarcin V, O-Deacetyl-ravidomycin
Source
Streptomyces sp.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Histone H3 and heat shock protein GRP78 are selectively cross-linked to DNA by photoactivated |gilvocarcin V in human fibroblasts. Matsumoto A. et al. Cancer Res. 2000, 60, 3921. |2. Chrysomycin derivative compounds and use as antitumor agents. US Patent 6,030,951, 2000. |3. Biochemical characterisation of elsamicin and other coumarin-related antitumour agents as potent |inhibitors of human topoisomerase II. Lorico A. et al. Eur. J. Cancer. 1993, 29A, 1985.
USBio References
No references available
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