Cycloheximide is an antibiotic produced by S. griseus. Its main biological activity is translation inhibition in eukaryotes, resulting in inhibition of protein synthesis leading to cell growth, cell arrest and cell death. CHX is widely used for selection of CHX resistant yeast and fungi strains; controlled inhibition of protein synthesis for detection of short-lived proteins and super-induction of protein expression; apoptosis induction or facilitation of apoptosis induction of death receptors.
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