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D1959-01 Dehydroaripiprazole-d8, Hydrochloride CAS: 1215383-78-0

Specifications
References
CAS Number
1215383-78-0
Grade
Highly Purified
Molecular Formula
C23H18D8Cl3N3O2
Molecular Weight
490.88
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl-d8]butoxy]-2(1H)-quinolinone Hydrochloride

A labeled metabolite of Aripiprazole, a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity.

Please note that users have reported separation of this compound and dehydroaripiprazole under normal-phase and reverse-phase HPLC conditions in a manner similar to that described in: Davis et al., Journal of Chromatography A, 731, (1996), 351-354 and Baweja, Journal of Liquid Chromatography, 9(12), (1986), 2609-2621.
Melting Point
123-125°C
Solubility
Methanol
Method for Determining Identity
‘H NMR Spectroscopic and Mass Spectrometric Analysis.
TLC Conditions
SiO2; Dichloromethane: Methanol: NH4OH; 9.2ml; 0.8ml: 4 drops; Visualized with UV and AMCS; Single spot; Rf=0.4.
Chloride Content
7.2%
Relative intensity of 7% D7, 0.2% D6, 0.004% D5, 0.0004% D4 and no D3, D2, D1 and D0 were detected.
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
References
Oshiro, Y., J. Med. Chem., 41, 658 (1998), Canive, J.M., et al.: Psychopharmacol. Bull., 34, 101 (1998).)
USBio References
No references available
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