D9025
CAS Number
117704-25-3Grade
Highly PurifiedMolecular Formula
C50H74O14Molecular Weight
899.11EU Commodity Code
38220090UN DOT Shipping
UN 2811 PGIIIShipping Temp
RTStorage Temp
-20°CDoramectin (25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1A, |25-Cylohexyl-avermectin B1, UK-67994, Dectomax)
25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin A1A; |25-Cylohexyl-avermectin B1; UK-67994; Dectomax
Doramectin is a biosynthetic avermectin derived from a mutant of the original Streptomyces avermitilis strain supplemented with a cyclohexylcaboxylic acid starting unit. Doramectin was developed as an anthelmintic for internal parasite control. The presence of the cyclohexyl group replacing the sec-butyl moiety affords greater hydrophobicity and longer biological half-life compared to avermectin. Like the other milbemycin/avermectins, it selectively binds to parasite glutamate-gated chloride ion channels and disrupts neurotransmission leading to paralysis and death of the parasite.
Melting Point
As Reported
Method for Determining Identity
Proton NMR (CD3OD) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions
As Reported
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards: All products should be handled by qualified personnel only, trained in laboratory procedures.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Dutton, C.J., et al.: J. Antibiot., 44, 357 (1991), 2. Lavy, E., et al.: Res. Vet. Sci., 75, 217 (2003)USBio References
No references available