E3222-30
CAS Number
11113-62-5Grade
Highly PurifiedMolecular Formula
C33H57N3O9Molecular Weight
639.8EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
-20°CEnniatin complex
Enniatins are a complex of depsipeptides produced by several Fusarium species. Typically, the complex contains 4 major components: A, A1, B and B1 together with minor amounts of enniatin C, D, E and F. The enniatins have been shown to act as ionophores. Recently, their effects on acyl-CoA cholesterol transferase, as nematocides and the selectivity of their antitumor action have received more focus.
Source: Fusarium sp. MST-FP1765
Apperance: White to off white powder
Solubility: Soluble in ethanol, methanol, DMF or DMSO.
Storage and Stability
May be stored at 4°C for short-term only. For long-term storage store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Source
Fusarium sp. MST-FP1765
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Ionophore antibiotics produced by the fungus Fusarium orthoceras var. enniatum and other Fusaria. Gaumann E. et al., Experientia 1947, 3, 202. 2. "Sandwich" complexation in cyclopeptides and its implications in membrane processes. Ivanov V.T., Ann. N. Y. Acad. Sci. 1975, 264, 221. 3. Interaction of cyclic peptides and depsipeptides with calmodulin. Mereish K.A. et al., Pept. Res. 1990, 3, 233. 4. Enniatin has a new function as an inhibitor of Pdr5p, one of the ABC transporters in Saccharomyces cerevisiae. Hiraga K. et al., Biochem. Biophys. Res. Commun. 2005, 328, 1119. 5. Enniatin exerts p53-dependent cytostatic and p53-independent cytotoxic activities against human cancer cells. Dornetshuber R. et al., Chem. Res. Toxicol. 2007, 20, 465.USBio References
No references available