(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide; |OR-611; Comtan; Comtess
Peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme involved in the metabolism of catecholamine neurotransmitters and related drugs. Antiparkinsonian.
Synonyms
(2E)-2-Cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide; OR-611; Comtan; Comtess
Molecular Formula
C14H15N3O5
Method for Determining Identity
1H NMR Spectroscopic Analysis
TLC Conditions
SiO2: Dichloromethane: Methanol: NH4OH; 9:1:0.1; Visualized with naked eye and UV; Single spot; Rf=0.4.
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
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