Technical Data

E3428-75
CAS Number
52044-54-7
Grade
Highly Purified
Molecular Formula
C27H41NO6S
Molecular Weight
507.68
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
Epothilone B (synthetic) (EpoB)
EpoB

Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumors. Epothilone B is what is known as a microtubule stabilizer. When a cell divides, the chromosomes that will end up in each cell are separated by thin filaments called microtubules. Normally these microtubules then break down as the cell division progresses. This class of cytotoxic chemo drugs prevents that break down and thus prevents cells from completing division.

Melting Point
95-97°C
Solubility
Chloroform, Dichloromethane, DMSO, Ethanol, Methanol
Determining Identity
Method for Proton (CDCl3) NMR Spectroscopic and Mass Spectrometric Analysis
Atmosphere
Inert gas
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap. Hygroscopic. Store under inert atmosphere.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
Bollag, D.M., et al.: Cancer. Res., 55, 2325 (1995), Hardt, I.H., et al.: J. Nat. Prod., 64, 847 (2001), Gerth, K., et al.: J. Antibiot., 55, 41, 45 (2002)
USBio References
No references available
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