E3428-75C
CAS Number
189453-10-9Grade
Highly PurifiedMolecular Formula
C27H41NO5SMolecular Weight
477.66EU Commodity Code
38220090Shipping Temp
RTStorage Temp
-20°CEpothilone D (KOS 862)
12,13-Deoxyepothilone B, EpoA; (4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione; (-)-Desoxyepothilone B; (-)-Epothilone D; KOS 862
Epothilones are polyketid. Potent microtubule stabilizer. Epothilone D is a more potent microtubule stabilizer in vitro than epothilone A or B. In vitro, Epothilone D showed potent cytotoxicity in a panel of human tumor cell lines, with similar potency to paclitaxel. It also showed definite advantage over paclitaxel in drug-resistant cell lines, and retained its cytotoxicity against a multidrug resistant cell line over-expressing P-glycoprotein.
Synonyms
12,13-Deoxyepothilone B, EpoA; (4S,7R,8S,9S,13Z,16S)-4,8-Dihydroxy-5,5,7,9,13-pentamethyl-16-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]oxacyclohexadec-13-ene-2,6-dione; (-)-Desoxyepothilone B; (-)-Epothilone D; KOS 862
Molecular Formula
C27H41NO5S
Appearance
White to off-white powder
Solubility
Dichloromethane, Ether, Ethyl Acetate, Methanol
Storage and Stability
Store at -20°C under inert atmosphere. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Brunden KR, Zhang B, Carroll J, Yao Y, Potuzak JS, Hogan AM, Iba M, James MJ, Xie SX, Ballatore C, Smith AB 3rd, Lee VM, Trojanowski JQ. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. J Neurosci. 2010 Oct 13;30(41):13861-6. doi:10.1523/JNEUROSCI.3059-10.2010. PubMed PMID: 20943926; PubMed Central PMCID: PMC2958430.USBio References
No references available