Geninthiocin CAS 158792-27-9

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G2024-66 Geninthiocin (14-Demethylberinamycin) CAS: 158792-27-9

Specifications

References

CAS Number

158792-27-9

Grade

Highly Purified

Molecular Formula

C50H49N15O15S

Molecular Weight

1132.1

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

+4°C

14-Demethylberinamycin

Geninthiocin, a thiopeptide antibiotic isolated from a Streptomyces sp., is a potent activator of the tipA gene, a bacterial transcription regulator involved in multidrug resistance. Geninthiocin displays a 10-fold selectivity for bacteria over mammalian cells lines.

Purity: >95% by HPLC

Solubility: Soluble in methanol, DMF or DMSO.

Source

Streptomyces sp.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Structural basis for antibiotic recognition by the TipA class of multidrug-resistance transcriptional |regulators. Kahmann J.D. et al. EMBO J. 2003, 22, 1824. |2. Microbial metabolites with tipA promoter inducing activity. II. Geninthiocin, a novel thiopeptide produced |by Streptomyces sp. DD84. Yun B-S. et al. J. Antibiot. 1994, 47, 969.