H2030-35C
CAS Number
91700-92-4Grade
Highly PurifiedMolecular Formula
C29H40N2O9Molecular Weight
560.6EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
4°C/-20°CHerbimycin C (Antibiotic TAN 420D)
Antibiotic TAN 420D
Herbimycin C is a minor analogue of herbimycin complex isolated from Streptomyces hygroscopicus. Herbimycin C possesses potent antitumor activity and has been shown to convert Rous sarcoma virus-infected rat kidney cells into normal cells. Until now limited access has restricted a full investigation of the properties of herbimycin C. Research on related metabolites, herbimycin A and geldanamycin has stimulated intensive interest in this class as selective antitumor agents and for prolonging the viability of tissue-cultured cells and organs.
Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. The structure and cytocidal activity of herbimycin C. Shibata K. et al. J. Antibiot. 1986, 39, 1630. 2. Natural product origins of Hsp90 inhibitors. Uehara Y. Curr. Cancer Drug Targets 2003, 3, 325. 3. Inducement of thermotolerance with benzoquinonoid ansamycins. Welch W.J. 2000 US Patent 6015659.USBio References
No references available