Jervine ((3ß,23ß)-17,23-Epoxy-3-hydroxyveratraman-11-one)
(3ß,23ß)-17,23-Epoxy-3-hydroxyveratraman-11-one
Has antibacterial properties. Jervine demonstrates teratogenic properties. It is the starting material for C-nor-D-homosteroids. Jervine induces holoprosencephaly and blocks endogenous Sonic hedgehog signaling.
Melting Point: 248- 250°C (decomposes)
Solubility: Chloroform (sparingly), Dichloromethane
Method for Determining Identity: Proton NMR spectroscopic analysis
TLC Conditions: SiO2; Dichloromethane: Methanol: Ammonium Hydroxide (90:10:1); Visualized with UV and AMCS; Single spot (Rf= 0.8).
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.