(+)-Amethopterin-methyl-d3, 4-Amino-10-methylpteroylglutamic-methyl-d3 Acid
Deuterated Methotrexate an antineoplastic and antirheumatic. A folic Acid antagonist.
Melting Point
>200°C (decomposes)
Solubility
DMSO; aqueous base
Specific Rotation
+17.8° (c= 0.4; 0.1N NaOH)
Method for Determining Identity
Proton NMR spectroscopic analysis and mass spectrometric analysis
TLC Conditions
C18; Acetonitrile : Water : Ammonium Hydroxide (8ml: 2ml: 10 drops). Visualized with UV an dAMCS (single spot; Rv=0.4).
Storage and Stability
Store at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Toxicity and Hazards
All products should be handled by qualified personnel only, trained in laboratory procedures.
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