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N0032-10 4-Amino-1-tert-butyl-3-(1’-naphthylmethyl)pyrazolo[3,4-d]pyrimidine (1-NMPP1, 1-NM-PP1) CAS: 221244-14-0

Specifications
References
CAS Number
221244-14-0
Grade
Highly Purified
MDL Number
MFCD17010191
Molecular Formula
C20H21N5
Molecular Weight
331.41
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
1-(1,1-Dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-NM-PP1

A highly potent (IC50=4.3 nM) and uniquely specific tyrosine kinase inhibitor of a rationally engineered v-Src tyrosine kinase.

Synonyms
1-(1,1-Dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine; 1-NM-PP1
CAS No
221244-14-0
Molecular Formula
C20H21N5
Molecular Weight
331.41
Purity
≥97% (HPLC)
Appearance
Beige solid
Melting Point
173-176°C
Solubility
Chloroform (Slightly), Methanol (Very Slightly)
Method for Determining Identity
Proton NMR Spectroscopic and Mass Spectrometric Analysis
TLC Conditions
SiO2; Ethyl Acetate: Hexane= 1:1; Visualized with UV and AMCS; Rf=0.30
Elemental Analysis
Calculated: %C: 72.48, %H:6.39, %N: 21.13
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt.
Source
Synthetic
Purity
~90%
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
References
1. Bishop, A.C., et al.: J. Am. Chem. Soc., 121, 627 (1999),. 2. Davies, S., et al.: Biochem. J., 351, 95 (2000). 3. Regan, J., et al.: J. Med. Chem., 45, 2994 (2002). 4. Bain, J., et al.: Biochem. J., 371, 199 (2003). 5. Kuma, Y., et al.: J. Biol. Chem., 280, 19472 (2005)
USBio References
No references available
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