N3500
CAS Number
9036-19-5Grade
Reagent GradeMolecular Weight
603EU Commodity Code
3822 0090UN DOT Shipping
UN3082 PGIIIShipping Temp
RTStorage Temp
RTNonidet-P40 substitute (NP40, NP-40, Igepal CA-630, T-DET O-series, ethoxylated octylphenol, T-DET O-9)
HM2076; Igepal CA-630; T-DET O-series; ethoxylated octylphenol; T-DET O-9; Nonidet P40 substitute
Nonidet-P40 is an anhydrous liquid nonionic surface- active agent produced by the reaction of octyl phenol with 8.5-9.5 moles of ethylene oxide. Nonidet-P40 (NP-40) is a nonionic surfactant used in the isolation of membrane complexes. This product has been reformulated to be eco-friendly. The only observable differences are that the viscosity and handling characteristics are somewhat modified. Due to its nonionic structure, this product is compatible with anionic surfactants and is stable in the presence of acids, bases, and salts. It should not be mixed with concentrated oxidizing or reducing agents since the mixture of these compounds with organic compounds could form a potentially explosive mixture. Nonidet-P40 is an effective emulsifier for solvents such as xylene.
Appearance
Colorless to pale yellow, clear, viscous liquid
Specific Gravity (25°C)
1.065
Viscosity (cP, 25°C)
~246
Surface Tension (0.1% aqueous, 25°C)
~30 dynes/cm
Cloud Point (1% aq)
64-68°C
Surface Tension (1% aq)
35 dynes/cm
Handling and Toxicity
Nonidet-P40 is regarded as non-hazardous. However, it is considered to possess low acute oral and skin penetration. It should not be used in products for internal use. Caution: This product causes eye irritation. Direct contact would likely result in corneal injury which might persist for a week or longer. Permanent damage is not likely to occur. However, if in contact with skin or eyes, flush with excess water and consult your physician.
Storage
Nonidet-P40 nonionic surfactants are stable non-corrosive products in their anhydrous state. They can be stored in plain steel tanks with piping, valves, and pumps of the same metal. Aqueous solutions of Nonidet-P40 must be stored in stainless steel or plastic lined tanks. The octyl phenol-ethylene oxide adducts are slightly hygroscopic. Where necessary, guard against atmospheric moisture pick-up, an inert gas blanket may be used.
Synonyms
Igepal CA-630; T-DET O-series; ethoxylated octylphenol; T-DET O-9; Nonidet P40 substitute
Related Products
Nonylphenylpolyethylene glycol; Polyethyleneglycol-p-isooctylphenyl ether; Octylphenoxy polyethoxy ethanol; Polyethylene Mono(nonylphenyl)ether Glycols; Polyoxyethylene (9) Nonylphenyl Ether; nonyl phenol ethoxylate; nonylphenyl polyethyleneglycol ether, nonionic; polyethylene glycol 450 nonyl phenyl ether, nonionic surfactant; Tergitol NP-9; polyethylene glycol 450 nonyl phenyl ether; Ethoxylated nonylphenol; alpha(nonylphenyl)-omega-hydroxypoly(oxy-1,2-ethanediyl); polyethylene glycols mono(nonylphenyl)ether; macrogol nonylphenyl ether; nonoxinol; polyoxyethylene(n)-nonylphenyl ether; nonylphenoxypolyethoxyethanol; nonylphenyl polyethylene glycol ether; nonoxynol; Makon; T-DET-N; surfionic n; sterox; arkopal N-090; carsonon N-9; igepal co-630; neutronyx 600; PEG-9 nonyl phenyl ether; protachem 630; rewpol hv-9; polyoxyethylene nonyl phenol; Glycols, polyethylene, mono(nonylphenyl) ether; Nonylphenol polyethylene glycol ether; Nonylphenol, polyoxyethylene ether; Nonylphenoxypoly(ethyleneoxy)ethanol; POE nonylphenol; Polyoxyethylene nonylphenol; POE (10) nonylphenol
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Chung, M.Y. et al., (2010) J Nutr Biochem. 12:1200-1206 2. Merchant, M. L. et al., (2009) Proteomics-Clinical Applications 4:84-96. 3. Shah, S.K. et al., (2010) Neurogastroenterology & Motility 22:1132–e290. 4. Burton, M.D. and Johnson, R.W. (2011) Brain, Behavior, and Immunity doi:10.1016/j.bbi.2011.10.008. 5. Thomas-Jardin, SE., et al. (2018). Prostate. doi: 10.1002/pros.23504. [Epub ahead of print].USBio References
1. Chung, M.Y. et al., (2010) J Nutr Biochem. 12; 1200-1206, 2. Merchant, M. L. et al., (2009) Proteomics-Clinical Applications 4:84-96. 3. Shah, S.K. et al., (2010) Neurogastroenterology & Motility 22; 1132–e290. 4. Burton, M.D. and Johnson, R.W. (2011) Brain, Behavior, and Immunity doi:10.1016/j.bbi.2011.10.008. 5. Thomas-Jardin, SE., et al. (2018). Prostate. doi: 10.1002/pros.23504. [Epub ahead of print]. 6. Nawas A.F., et al. IL‐1 induces p62/SQSTM1 and autophagy in ERα+/PR+ BCa cell lines concomitant with ERα and PR repression, conferring an ERα−/PR− BCa‐like phenotype. 2018. J Cell Biochem. doi: 10.1002/jcb.27340. [Epub ahead of print].|7. Speidel JT., et al. 2018. Bisphenol A (BPA) and bisphenol S (BPS) alter the promoter activity of the ABCB1 gene encoding P-glycoprotein in the human placenta in a haplotype-dependent manner. Toxicol Appl Pharmacol. 359:47-54. |8. Park HR and Loch-Caruso R. 2015. Protective effect of (±)α-tocopherol on brominated diphenyl ether-47-stimulated prostaglandin pathways in human extravillous trophoblasts in vitro. Toxicol In Vitro. 29(7):1309-1318. doi: 10.1016/j.tiv.2015.05.015