PD184352 CAS 212631-79-3

CAS Number

212631-79-3

Grade

Highly Purified

MDL Number

MFCD02683961

Molecular Formula

C17H14ClF2IN2O2

Molecular Weight

478.66

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide

PD184352 is an inhibitor of mitogen activated protein kinase kinase (MEK or MAPKK).

Solubility

Soluble in DMSO at 50mg/ml; soluble in ethanol at 8.3mg/ml with slight warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 5-10uM. buffers, serum, or other additives may increase or decrease the aqueous solubility.

Melting Point

As Reported

Elemental Analysis

Calculated C - 42.66% H - 2.95% Cl - 7.41% F - 7.94% I - 26.51% N - 5.85%

Storage and Stability

Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with DMSO. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Keep cool and dry.

Purity

≥99% (HPLC and TLC)

Form

Supplied as a white to off-white powder

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Chang Y. et al., (2012) FASEB J. doi:10.1096/fj.12-208033. 2. Chang Y et al. 2014. Respiratory Research. 15:145. 3. Farias R and Rousseau S. (2016). Front Cell Dev Biol. 3:87. doi: 10.3389/fcell.2015.00087. eCollection 2015.

USBio References

1. Chang Y. et al., (2012) FASEB J. doi:10.1096/fj.12-208033. |2. Chang Y, et al. Upregulation of IL-17A/F from human lung tissue explants with cigarette smoke exposure: implications for COPD. Respiratory Research. 2014. 15:145.|3. Farias R and Rousseau S. 2016. The TAK1→IKKβ→TPL2→MKK1/MKK2 Signaling Cascade Regulates IL-33 Expression in Cystic Fibrosis Airway Epithelial Cells Following Infection by Pseudomonas aeruginosa. Front Cell Dev Biol. 3:87. doi: 10.3389/fcell.2015.00087. eCollection 2015.|4. Saidi H., et al. Involvement of Alveolar Macrophages and Neutrophils in Acute Lung Injury After Scorpion Envenomation: New Pharmacological Targets. 2018. Inflammation. 41(3):773-783.

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P3120-55B PD184352 (Cl-1040, 2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide) CAS: 212631-79-3

CAS Number

Grade

MDL Number

Molecular Formula

Molecular Weight

EU Commodity Code

Shipping Temp

Storage Temp

2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide

References

USBio References

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