Technical Data

P4198-55
CAS Number
112529-15-4; freebase: 111025-46-8
Grade
Highly Purified
Molecular Formula
C19H20N2O3S•HCl
Molecular Weight
392.9
EU Commodity Code
38220090
Shipping Temp
RT
Storage Temp
-20°C
Pioglitazone Hydrochloride
5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione Hydrochloride; 5-phenyl]methyl-2,4-thiazolidinedione; AD-4833; Actos; U-72107A

Used as an antidiabetic.

Synonyms
5-[[4-[2-(5-Ethyl-2-pyridinyl]ethoxy]phenyl]methyl]-2,4-thiazolidinedione Hydrochloride; 5-phenyl]methyl-2,4-thiazolidinedione; AD-4833; Actos; U-72107A
CAS No
112529-15-4; freebase: 111025-46-8
Molecular Formula
C19H20N2O3S•HCl
Molecular Weight
392.9
Appearance
White solid
Purity
≥98%
Melting Point
>187ºC (dec)
Solubility
DMSO (Slightly), Methanol (Slightly)
Method for Determining Identity
Proton NMR (DMSO-d6) Spectroscopic and Mass Spectrometric Analysis
TLC Conditions
SiO2: Dichloromethane: Methanol: Ammonium Hydroxide; 9: 1: 0.1; Visualized with UV and KMnO4; Single spot, Rf=0.45
Chloride
~9%
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. Stable for 6 months after receipt. For maximum recovery of product, centrifuge the original vial prior to removing the cap.

Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.

References
1. Hofmann, C., et al.: Endocrinology, 129, 1915(1991). 2. Kobayashi, M., et al.: Diabetes, 41, 476 (1992). 3. Kawaamori, R., et al.,: Diabetes Res. Clin. Pract., 41, 35 (1998).|Product-Specific Reference:|1. Yeligar SM, et al. 2017. Dysregulation of Alveolar Macrophage PPARγ, NADPH Oxidases, and TGFβ1 in Otherwise Healthy HIV-Infected Individuals. AIDS Res Hum Retroviruses. 33(10):1018-1026. doi: 10.1089/AID.2016.0030.
USBio References
1. Yeligar SM, et al. 2017. Dysregulation of Alveolar Macrophage PPARγ, NADPH Oxidases, and TGFβ1 in Otherwise Healthy HIV-Infected Individuals. AIDS Res Hum Retroviruses. 33(10):1018-1026. doi: 10.1089/AID.2016.0030.
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