P9005-85
CAS Number
82-89-3Grade
Highly PurifiedMolecular Formula
C20H25N3OMolecular Weight
323.4EU Commodity Code
38220090Shipping Temp
Blue IceStorage Temp
-20°CProdigiosin
Prodigiosin is an intensely red pyrrole pigment produced by several bacteria, most notably, Serratia marcescens. Prodigiosin has a broad biological profile with activity against fungi, tumor cell lines and malaria. It was shown to be an immunosuppressant in 2007. The mode of action of prodigiosin has recently received considerable attention as an inducer of apoptosis in human primary cancer cells via caspase activation. Prodigiosin also acts as an inducer of p21WAF1/CIP1 expression via transforming growth factor-B receptor pathway, and of NAG-1activation by acting on glycogen synthase kinase-3B.
Solubility: Soluble in ethanol, methanol, DMF or DMSO. Limited water solubility
Storage and Stability
May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.
Source
Serratia marcescens MST-AS5330
Form
Supplied as a dark red solid.
Important Note
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.
Intended for research use only. Not for use in human, therapeutic, or diagnostic applications.
References
1. Seeing red: The story of prodigiosin. Bennett J.W. & Bentley R., Adv. Appl. Microbiol. 2000, 47, 1. 2. Prodigiosin induces apoptosis of B and T cells from B-cell chronic lymphocytic leukemia. Campas C. et al., Leukemia 2003, 17, 746. 3. Prodigiosin: a novel family of immunosuppressants with anti-cancer activity. Pandey R. et al., Indian J. Biochem. Biophys. 2007, 44, 295. 4. The anticancer agent prodigiosin induces p21WAF1/CIP1 expression via transforming growth factor- beta receptor pathway. Soto-Cerrato V. et al., Biochem Pharmacol. 2007, 74, 1340. 5. Prodigiosin induces the proapoptotic gene NAG-1 via glycogen synthase kinase-3beta activity in human breast cancer cells. Soto-Cerrato V. et al., Mol. Cancer Ther. 2007, 6, 362. 6. Proteomic analysis of prodigiosin-induced apoptosis in a breast cancer mitoxantrone-resistant (MCF-7 MR) cell line. Monge M. et al., Invest. New Drugs 2007, 25, 21.USBio References
No references available