Reticulol CAS 26246-41-3

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R1650-35 Reticulol (6,8-Dihydroxy-7-methoxy-3-methylisocoumarin) CAS: 26246-41-3

Specifications

References

CAS Number

26246-41-3

Grade

Highly Purified

Molecular Formula

C11H10O5

Molecular Weight

222.2

EU Commodity Code

38220090

Shipping Temp

Blue Ice

Storage Temp

-20°C

6,8-Dihydroxy-7-methoxy-3-methylisocoumarin

Reticulol is an isocoumarin metabolite produced by selected species of Streptomyces. Reticulol was first described as a potent inhibitor of cyclic nucleotide phosphodiesterase but more recent research has demonstrated a topoisomerase I inactivation mechanism. Reticulol has also been demonstrated to cause a dose dependent inhibition of lung metastasis in the B16F10 melanoma model.

Purity: >95% by HPLC

Solubility: Soluble in ethanol, methanol, DMF or DMSO

Source

Streptomyces sp.

Important Note

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications without the expressed written authorization of United States Biological.

References

1. Topoisomerase I inactivation by reticulol and its in vivo cytotoxicity against B16F10 melanoma. Lim D.S. |et al. Chemotherapy 2003, 49, 257. |2. Antitumor efficacy of reticulol from Streptoverticillium against the lung metastasis model B16F10 |melanoma. Lung metastasis inhibition by growth inhibition of melanoma. Lim D.S. et al. Chemotherapy |2003, 49, 146. |3. Reticulol, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase. Furutani Y. J. |Antibiot. 1975, 28, 558. |4. Reticulol, a new metabolic isocoumarin. Mitscher L.A. et al. Experientia 1964, 20, 258.