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R1900-02 RO 20-1724, cAMP-specific Phosphodiesterase Inhibitor CAS: 29925-17-5

Specifications
References
CAS Number
29925-17-5
Grade
Highly Purified
Molecular Formula
C15H22N2O3
Molecular Weight
278.33
EU Commodity Code
38220090
Shipping Temp
Blue Ice
Storage Temp
-20°C
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone

Cell-permeable. A potent, selective, cAMP-specific phosphodiesterase inhibitor (PDE IV, IC50 = 2uM). Inhibits superoxide generation and platelet aggregation stimulated by arachidonic acid. Also inhibits fMLP-induced neutrophil adhesion to vascular endothelial cells.

Synonyms
4-(3-Butoxy-4-methoxybenzyl)-2-imidazolidinone
CAS No
29925-17-5
Molecular Formula
C15H22N2O3
Molecular Weight
278.33
Appearance
White to off-white solid
Purity
≥95%
Solubility
DMSO (~200mg/ml) or EtOH (~40mg/ml).
Storage and Stability
Lyophilized powder may be stored at -20°C. Stable for 12 months after receipt at -20°C. Reconstitute with DMSO or EtOH. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer. Light sensitive.
References
Derian, C.K., et al. 1995. J. Immunol. 154, 308.|Rubin, L.L., et al. 1991. J. Cell Biol. 115, 1725.|Lad, P.M., et al. 1985. Biochim. Biophys. Acta 846, 286.|Bergstrand, H., et al. 1977. Mol. Pharmacol. 13, 38.
USBio References
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